
I very much enjoy PHP and use it with some regularity. Javascript has some limitations, but the AJAX framework is taking care of at least part of that. I have done a little Perl, but not enough to have an opinion. Ruby is suspect in my mind for scalability reasons. Python rocks.
But I have never seen a word processor, or a graphics package, or anything else (except maybe Plurk) running in a browser, written in any of these languages that can hold a candle to a compiled app running locally. Part of that is the intimacy with the hardware, which is hard to attain without serious security issues. Part of it is speed; our connections to the internet are not as fast as our local bus.
But I think part of it is also the languages themselves. I will know that these problems have been solved when someone starts marketing a Web word processor as agile as Word or a Web graphics package as good and full-featured as Photoshop. That time has not yet come.






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